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The most common side effects during initiation are gastrointestinal, including nausea, vomiting, and diarrhoea, which are generally dose-dependent and transient

FFA3 is expressed in the enteric sympathetic ganglion (Nhr et al., 2015) and the GLP-1R is expressed in vagal afferent neurons including the nodose ganglion (Zhang et al., 2020), suggesting the possibility of functional interactions between these two receptors at these neuronal locations