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The mechanism of its pathogenesis is not fully understood, multiple parallel hits are believed to be involved, including insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors ( In recent years, more and more attention has been paid to intestinal flora and its metabolites

For most people, current research and clinical experience suggest Ozempic is safe to use for years, particularly in type 2 diabetes where the trade-off between glucose control and side effects clearly favours staying on it

While the routinely available dopaminergic drugs listed in table 1, alone or as part of a combination regimen, allow for effective control of motor symptoms in a majority of patients over many years, unmet needs remain regarding efficacy as well as safety, tolerability and prevention of long-term motor complications

69 In comparison, newer oral small-molecule GLP-1 RAs, such as danuglipron and orforglipron, have demonstrated similar efficacy