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Normal aging is accompanied by a decline in cerebral metabolism, driven by impaired mitochondrial ATP production, increased reactive oxygen species (ROS), and decreased antioxidant defenses (Maldonado et al., 2023), and these deficits are amplified in ADRD compared to cognitively normal older adults (Patro et al., 2021

Journal of Neurochemistry 97, 1634-1658CrossRefGoogle ScholarPubMed 7Lin, M.T