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Further, NASO B12 was well-tolerated throughout the treatment period.[] Patients on metformin therapy receiving NASO B12 should also be instructed that they will require weekly intranasal administration of NASO B12 spray in each nostril after correction of vitamin B12 deficiency for the remainder of their lives

The 20.9% mean body weight reduction seen in SURMOUNT-1 at 72 weeks reflects tirzepatides direct receptor binding and metabolic effects, not secondary antioxidant support

No detectable debutyrylation was observed at other sites (Fig

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