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By contrast, GSH reductase uses nicotinamide adenine dinucleotide phosphate to catalyze the reduction of GSSG to generate GSH, thereby reducing reactive oxygen species (ROS) in the intracellular cyclic environment and maintaining redox homeostasis (16)

Fistulas are a major Crohns disease complication, and this is one of the more clinically relevant preclinical findings

The depletion of GSH may also allow viruses to replicate, and therefore is a major factor in the pathology of COVID-19 [36]