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Moreover, the FDA-approved anticoagulant drug warfarin, a small-molecule inhibitor of VKORC1L1, suppresses tumor growth by inducing ferroptotic cell death in vivo, indicating that warfarin may be a potential anticancer drug, especially for cancer patients with high VKORC1L1 expression

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We use experimentally determined forms for these allosteric interactions but sometimes the details of the kinetics are not known, forcing us to make reasonable educated guesses

Hardiman O, Van Den Berg LH, Kiernan MC (2011) Clinical diagnosis and management of amyotrophic lateral sclerosis