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Where the research should go next Key open questions include how much endogenous GLP1 increase is needed for sustained weight change, whether combinations of diet, prebiotics, probiotics and nutraceuticals can match injectable outcomes, and the longterm safety of such combinations

GLP-1 drugs show real promise in supporting brain health, especially in people with metabolic diseasebut they are not yet a guarantee against dementia

September 2025: Pfizer announced its agreement to acquire Metsera in a deal valued at up to USD 7.3 billion, strengthening its pipeline of next-generation GLP-1, amylin, and obesity therapies

Exp Med Surg