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If side effects are moderate to severe, remain at 0.25mg for an additional 35 days before escalating

Yet that randomized control trial included a more general population, not specifically participants with PCOS

B12 injections can be particularly beneficial for those who: Follow a vegan or vegetarian diet Have digestive conditions like Crohns disease or celiac disease Experience chronic fatigue or anaemia Are over the age of 50 Are pregnant or planning to conceive How Often Should You Get a B12 Shot

2 The clearest human quantification of this effect comes not from cagrilintide but from pramlintide, and it is worth stating the numbers precisely because they anchor the entire mechanistic claim