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5 (3), 385391 (2012) N.R

The neurotoxic effects of mHtt are mediated by the induction of mitochondrial defects, which in turn result in aberrant energy metabolism and HD-related neuronal dysfunction ( Studies have demonstrated that mHTT interacts with the PGC-1 promoter, directly impairs the activity of PGC-1, and impedes the capacity of PGC-1 to open downstream target genes (Hu et al., 2025)

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Once completed, the cells were washed with media one time, then 2 mls of vehicle or conditioned media were added to the wells