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There's research suggesting an association between estrogen and cognitive function, and the timing hypothesis is relevant here too: early initiation of HRT is studied differently than late initiation for cognitive outcomes
Consistent with the base-case analysis, sensitivity analyses demonstrated that using GLP-1RAs versus insulin was either cost-saving or cost-effective, except for the analyses where the treatment effectiveness was estimated based on the AT scenario in the second and third sensitivity analyses, showing that a GLP-1RA versus insulin therapy was not cost-effective for averting one case of all-cause death from the payer perspective
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