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However, chronic high-volume fasted cardio can elevate baseline cortisol and disrupt sleep quality, which indirectly impairs the nocturnal GH pulse that the peptides are designed to amplify
Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates
However, some patients find that injecting on a rest day (rather than before a workout) reduces exercise-related nausea and allows them to maintain consistent training intensity