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However, its application in topical formulations is severely hindered by its rapid oxidation, intrinsic instability, and poor permeability across the stratum corneum

At the same time, if verified peptide formulations were ultimately shown to enhance soft-tissue recovery without increasing infection risk, the clinical relevance for TJA would be substantial, underscoring the importance of rigorous clinical investigation rather than informal adoption

The main goal of treatment is to find the most effective combination of therapies that can provide long-term symptom relief

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