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Hum Mol Genet (2014) 23(3):8109.10.1093/hmg/ddt463 123 KamensHMCorleyRPRichmondPADarlingtonTMDowellRHopferCJet alEvidence for association between low frequency variants in CHRNA6/CHRNB3 and antisocial drug dependence

Potential Risks Since CJC 1295 stimulates GH production, it may also come with GH-related side effects , especially at higher doses or prolonged use: Joint Pain & Stiffness: Increased GH can lead to joint discomfort, particularly in the wrists and fingers

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Evening hours bring increased cold sensitivity for many, possibly related to natural circadian rhythm temperature fluctuations