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In addition, a novel DPP-4 inhibitor anagliptin, was investigated as a potential therapeutic in atherosclerosis, and its treatment improved TNF- , IL6 , and MCP-1 secretion in VSMC, reduced telomerase activity, and reversed upregulated SIRT1 in IL-1 treated cells

The degradation of glutathione by GGT recruits amino acids, notably Cys, to cells, but also produces -glutamyl peptides extracellularly under certain circumstances

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L-Glutathione (GSH) is a thiol-containing tripeptide that acts directly as an antioxidant, neutralizing reactive oxygen species, free radicals, peroxides, and lipid peroxides