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It is clear that GLP-1 is taken up by proopiomelanocortin (POMC) cells within the arcuate nucleus, and these neurons are depolarized by application of GLP-1(Secher et al., 2014)

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Difficult timing: John explains that oral semaglutide must be taken on an empty stomach and requires a 30-minute wait before eating, which can be hard to maintain long-term

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