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Semaglutide was first introduced as Ozempic to help manage type 2 diabetes

It mimics both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide), another hormone that influences insulin production and hunger cues

Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects

Eating smaller, more balanced meals and staying hydrated can further minimize digestive discomfort while allowing the appetite-suppression benefits to emerge