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The above studies screened potential beneficiary populations through biomarkers (CD8 + T cells or E-cadherin), providing a basis for overcoming drug resistance and developing precision treatment strategies (96)

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Increased colocalization of GPX4 with the autophagy marker microtubule-associated protein 1 light chain 3 (LC3) promoted autophagic degradation of GPX4

Mast Cell Hyper-Reactivity (MCAS): As a potent antioxidant, glutathione neutralizes the reactive oxygen species that directly trigger mast cell degranulation, helping to stabilize these immune cells and reduce the systemic release of inflammatory mediators