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This creates a practical and financial dilemma

Patients should be counselled that it may typically take 812 weeks or longer to experience the full therapeutic benefit, given the time required to reach steady state and for metabolic adaptations to occur, though this varies between individuals

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Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15