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Given the limitations of the in vitro model using one human adipocyte cell line, further studies are necessary to confirm the hypothesis that nutrients, by stimulating the secretion of GLP-1, may influence the expression of irisin and thus modulate the mitochondrial metabolism of adipocytes.

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Nat Rev Clin Oncol (2021) 18(5):28096

This structural difference influences their interaction with the body's melanocortin receptors and, consequently, their physiological and therapeutic effects [5]