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In humans, DPP4 found in the brush borders of epithelial cells of the proximal convoluted tubules in the kidney and of the small and large intestine as well as in prostate tissue, liver hepatocytes, and activated leukocytes (T-, B- and natural killer cells)

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The functional effects of GLP-1 analogues on human eosinophils appear to be linked to their ability to reduce LPS-induced membrane expression of CD69 and CD11b, along with the synthesis of cytokines like IL-4, IL-8, and IL-13 [129]