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Semaglutide may cause acute kidney injury or worsen chronic kidney disease, potentially requiring dialysis

An important mediator in the process of reduced feelings of hunger is the hormone leptin, which, in interaction with GLP-1, regulates satiety and controls reward and aversion, suppressing hunger by inhibiting the appetite inducers AgRP/NPY neurons, while stimulating the satiety inducers POMC neurons [17,118,119]

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According to the Rybelsus SmPC (available on the Electronic Medicines Compendium) and the EMA's European Public Assessment Report (EPAR), oral semaglutide uses a proprietary absorption enhancer called SNAC (sodium N-[8-(2-hydroxybenzoyl) aminocaprylate]) to facilitate absorption through the gastric mucosa