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For instance, mice on a high-fat diet exposed to polystyrene MPs exhibited enrichment of Desulfovibrio and Clostridium and a marked reduction in Lactobacillus and Bifidobacterium [74]
Similar results are also obtained from clinical studies, especially from patients with IBD, that show impact of gut microbes on the mucosal oxidative stress
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Reduced folic acid and methionine lead to a compromised supply of methyl moiety for epigenetic and metabolic regulation, in turn aggravating apoptosis and DNA damage in cultured hippocampal neurons [40,41]
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