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Research published in Cell Metabolism found that tirzepatide did not prevent the metabolic slowdown that normally accompanies weight loss, but it significantly increased fat oxidation

A., Guarino-Vignon, P., Fatouh, R., Dubois, L., Creusot, L., Puchois, V., Amouyal, S., Alonso Salgueiro, I., Bredon, M., Chollet, L., Ledent, T., Scandola, C., Auger, J

Further glucagon actions include the improvement of the whole body lipid metabolism and the promotion of hepatic fatty acid oxidation which may provide therapeutic actions for MASLD and/or MASH [60]

Functionalizing J211 with Lys(-(AEEA) 2 -E-stearate) (C 18 lipid dicarboxylate) at position 26 yielded mono-lipidated J229 (Fig