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IGF-1 LR3 in Stem Cell Self-Renewal Research Research has established that IGF-1 receptor signalling is necessary for human embryonic stem cell self-renewal, and that IGF-1 LR3 can substitute for native IGF-1 in stem cell cultures with increased potency and stability requiring lower concentrations for equivalent or superior biological effects compared to unmodified IGF-1

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Triple agonist receptor pharmacology explored as a tool for understanding coordinated GLP-1, GIP, and glucagon receptor activation and their combined metabolic effects