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To further support the negative impact of meningeal T H 17 immunity on cognitive performance in AD, we assessed the level of T H 17 cells in intestinal-associated tissues of specific-pathogen-free (SPF) relative to germ-free (GF) 5xFAD mice, previously reported to significantly outperform conventional 5xFAD mice in cognitive tests 57

A total of 80 participants with obesity or overweight were treated with ascending doses of AM833 in combination with 2.4 mg semaglutide once-weekly (141)

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