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Fig 2: Evolving Competitive Landscape in GLP-1 Based Obesity Medications Abbreviations: AHI: Apnea Hyperpnea Index, CKD: Chronic Kidney Disease, MONW: Metabolic Obesity Normal Weight, OOP: Out-of-pocket, OSA: Obstructive Sleep Apnea, WRC: Weight- related comorbidity

Although these trials are valuable, they were excluded within the scope of this review because they lacked head-to-head comparison with prandial insulin

with GLP-1 drugs causing diarrhea in up to ~30% and vomiting in up to ~24.5% of semaglutide users, persistent GI losses during dose escalation can drop serum potassium below 3.5 mEq/L (hypokalemia), causing muscle weakness, cramps, palpitations, and dangerous arrhythmias

Available from: Singh, K., Aulakh, S