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The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus

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These changes result from the direct effect of GLP-1RAs on proinflammatory cytokines production in monocytes/macrophages as it blocks NF-B, and lowers the formation of pro-inflammatory M1 macrophages

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For GI-receptor targeted prototypes, it is not clear how such a particle avoids surface premature binding from protein and lipids in the GI tract

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Specific genetic variations, including changes in certain genes, are associated with a higher risk of type 2 diabetes

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