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By promoting autophagy via the mitogen-activated protein kinases signaling pathway, PNO1 mainly affects the levels of intracellular glutamate, which activates system Xc- to import additional cysteine

Cellular Protection and Anti-Aging Properties Recent studies have shown glutathione's role in cellular longevity and protection against age-related decline

Moreover, in a model of immune tolerance induced by LPS in volunteers, -glucan can partially reverse LPS-induced immune tolerance by modulating the cellular epigenome, which allows elevated expression of H3K27ac, thereby restoring the ability of M to produce pro-inflammatory cytokines (197)