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The result is gas buildup in the upper GI tract that gets released as sulfur-scented burps, sometimes accompanied by a feeling of bloating, nausea, or general stomach discomfort that many people notice early in treatment
Absolute contraindications include personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), previous serious hypersensitivity to semaglutide or formulation components, pregnancy (the medication should be discontinued at least 2 months before planned conception), and breastfeeding due to insufficient data on excretion in human milk
The trials target distinct populations: obesity or overweight without type 2 diabetes (TRIUMPH-1), with type 2 diabetes (TRIUMPH-2), severe obesity with established cardiovascular disease (TRIUMPH-3), and obesity with knee osteoarthritis (TRIUMPH-4)
It stimulates muscle cell growth and prevents muscle breakdown
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