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3.2 Neuroinflammation and CKD CKD is increasingly recognized as a condition that affects not only the kidneys but also has systemic effects, including on the CNS, often contributing to neuroinflammation
J., Brioche T., et al
The transcriptional program orchestrated by NRF2 activation encompasses a broad range of cytoprotective genes, including those encoding phase II detoxification enzymes, such as NAD(P)H quinone oxidoreductase 1 (NQO1), glutathione S-transferases (GSTs), and heme oxygenase-1 (HO-1), which play crucial roles in neutralizing toxic compounds and reactive metabolites [81]
Comas-Bast O, Snchez-Prez S, Veciana-Nogus MT, Latorre-Moratalla M, Vidal-Carou MC
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