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Additionally, NSAIDs like salasate and acetylsalicylic acid exhibit strong anti-inflammatory properties by inhibiting NF-B

The expression of CYP2J, a member of P450 subfamily with a role in the bioactivation of AA in extrahepatic tissues, inhibits NF-B and MAPK signaling pathways and activates of PPAR, thus reducing IR and diabetic phenotype [173]

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In their study, Maeda and Nelson also examined whether the ratio of MA prices to FFS prices varied across DRGs to assess whether there were certain DRGs for which MA plans tended to pay more or less than FFS