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Fe 3+ binds to Tf forming holo-Tf, which undergoes endocytosis via TfR1 on brain microvascular endothelial cells (BMECs)

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In an embodiment, is a compound of Formula I, or a pharmaceutically acceptable salt thereof, wherein none of X 30 , X 31 , X 32 , X 33 , X 34 , X 35 , X 36 , X 37 , X 38 , X 39 , and X 40 is C or is a substituent that contains a fatty acid