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The European Association for the Study of the Liver (EASL) clinical practice guidelines on Wilson disease note that hepatic copper exceeding 250 mcg/g dry weight is a strong diagnostic criterion for Wilson disease, but subclinical copper accumulation can begin at much lower thresholds in patients with cholestatic or cirrhotic liver disease [2]

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Likewise, BPC 157 may interfere with prostaglandin system activities, that is, it strongly counteracts NSAIDs toxicity (Sikiric et al., 2013), much like it counteracts developing and already formed adjuvant arthritis in rats (Sikiric et al., 1997c)