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10.1111/febs.16344 157 ZhangX.ZhouK.WangR.CuiJ.LiptonS

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Core mechanisms underlying these effects include mTORC1 pathway overactivation, mitochondrial dysfunction, inflammatory activation, and metabolic intermediate accumulation.However, it must be emphasized that the harmful effects of BCAAs primarily occur in pathological states with impaired metabolic function, whereas at physiological levels in healthy individuals, BCAAs are essential nutrients