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Lysosomal signaling promotes longevity through adjusting mitochondrial activity graphical abstract

To investigate the importance of sAC in GLP-1(2836)stimulated cAMP generation in human caECs, we also blocked the anion (HCO 3 ) entry required for sAC activity using probenecid (39)

Furthermore, emerging strategies, such as acetazolamide combined with remote ischemic preconditioning (RIPC), have shown additional risk reductions under controlled hypoxia exposure

Once inside the hepatocyte, bilirubin binds to intracellular proteins, including glutathione S-transferases, which stabilize the molecule and prevent it from diffusing back into circulation [25]