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While inhaled corticosteroids like budesonide can have minimal systemic absorption, the risk of decreased bone mineral density is primarily associated with long-term, high-dose use rather than short-term or intermittent rescue use of Airsupra

CX and ZG were involved in revising the manuscript

Induced pluripotent stem cell-derived MSCs (iPSC-MSCs) activate CD4+ and CD8 + T cells, upregulate and activate Treg cells, and balance Th1/Th2 cytokine levels without any additional stimulation [147]

in fact, studies have shown that secretion of sCD8 is particularly marked during the active phase of Graves' disease (Watanabe, 1997)