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One mechanism by which butyrate may function is to inhibit the activation of the proinflammatory cellsignaling component nuclear factor kappa B (NF-kB) (Segain 2000)

Glycine induces ferroptosis in RA-FLSs via S-adenosylmethionine (SAM)-associated methylation of GPX4 promoter, further enhancing ferroptosis efficacy by downregulating FTH1 expression