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Preclinical data in glioblastomas showed that a single implant markedly reduced local recurrence and produced a median survival benefit, while pharmacokinetic studies showed therapeutic intraparenchymal temozolomide levels for over four weeks with minimal systemic exposure

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A plausible explanation is that bile acid concentration decreases in the short term (13 months) after weight loss, but increases in the long term (15 years) after surgery

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Cheong, J

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