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10.1111/obr.12964 33 DunneF.NewmanC.Alvarez-IglesiasA.FergusonJ.SmythA.BrowneM.et al (2023)

Older adults and those with compromised antioxidant systems may require lower starting doses with gradual titration based on tolerance and biomarker response

Measurable changes in fasting glucose and subjective energy typically appear within 710 days, while body composition shiftsreduced visceral adiposity and improved lean mass ratiobecome evident at 46 weeks with consistent dosing

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