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Epigenetics refers to long-lasting changes in gene expression that are regulated by transcriptional, post-transcriptional, intra- or post-translational mechanisms (such as DNA methylation, histone modifications, and microRNA regulation) that do not involve DNA sequence alteration and are usually characterized by stability and longevity [84]

It pools data from multiple independent studies each with its own patients, methods, and researchers into a single statistical analysis

The diagnosis helps to rule out other more serious conditions and can help to manage the symptoms and treat the condition