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Supportive of a genetic component, lipedema has been reported in children (32) and as early as infancy by some women

These appear to implicate hitherto unrecognized metabolic mechanisms induced by fasting: antioxidative defense (ergothioneine, OA, carnosine), enhanced mitochondrial activity (organic acids in the TCA cycle), increased purine and pyrimidine anabolism, pentose phosphate pathway (sedoheptulose-7-phosphatase, pentose phosphate), and remodeling of signaling (hydroxybutyrate)

Below is a look at how these compounds differ as well as how they are alike