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Obesity is a key driver of the most prevalent cardiometabolic diseases, serving as a critical factor in the development of cardiovascular disease, such as ischemic heart disease and stroke [11], and constituting the leading modifiable cause of type 2 diabetes [12]

Published online Dec 16, 2016

This is of potential clinical relevance, as further defining the commonalities and differences between GLP-1R agonists and bariatric surgery in terms of their central mechanism of action may not only help bridge the gap between the pharmacological and surgical treatments for obesity but may also provide a neural basis for their combined use when each individually fail [174, 175]