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Safety Profile (Phase 2) The most common adverse events were gastrointestinal and consistent with the incretin drug class: - Nausea - Diarrhea - Vomiting - Constipation - Decreased appetite These GI events were dose-related, mostly mild to moderate, and partially mitigated by starting at a lower initial dose (2 mg vs

[8] This highlights the importance of diet in modulating the gut microbiome to affect the skin

Meric-Bernstam F, Johnson A, Holla V, Bailey AM, Brusco L, Chen K, Routbort M, Patel KP, Zeng J, Kopetz S, Davies MA , Piha-Paul SA, Hong DS, Eterovic AK, Tsimberidou AM, Broaddus R, Bernstam EV, Shaw KR, Mendelsohn J, Mills GB

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