In phase 3 trials, after 56 weeks of treatment, 62% of patients receiving contrave 32 (bupropion SR 360 mg/naltrexone SR 32 mg) lost at least 5% of their body weight as compared to 23% of patients in the placebo group [240]
Patients report less burning with a subcutaneous administration, which gives it a slight advantage over an intramuscular injection, according to the CDC
While some studies tend to prove that B12 shots may give them an extra boost of energy, which, in turn, may be associated with becoming more physically active, it should be highlighted that this is not the equivalent of some automatic or magical means toward losing weight
These include vitamin B12 deficiency and malabsorption that is caused by the following medical conditions, according to the NIH [1]: Pernicious anemia Tropical sprue Pancreatic insufficiency Surgery in the gastrointestinal tract Certain medications Deficiency in the diet Side effects of B-12 injections Also, according to the NIH, vitamin B-12 injections have some potential side effects, including [1]: Diarrhea Itching Swelling Risk of allergic reaction and anaphylaxis Can Vitamins Aid in Weight Loss
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