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We acknowledge that there is a risk a hospital might take advantage of the 35 percent reduction to the CMP to avoid affirmative efforts to comply with the HPT requirements until CMS conducts an audit and identifies the violations, however, we believe this risk to be minimal and mitigated by the fact that hospitals are not eligible for the 35 percent reduction in CMPs if they receive a subsequent CMP for the same violation

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Researchers modeling repeat-dose experiments generally aim to reach steady-state concentrations after four to five half-lives of continuous administration

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