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Conclusions Subcutaneous infusion using a subcutaneous catheter system and a portable pump for OHCbl administration in combined and isolated remethylation disorders is safe, acceptable, and effective

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To further investigate why these three missense mutations led to a significantly increased GLP-1R ECD affinity of semaglutide mutant 524, a comprehensive structural biophysical analysis [50] was conducted for the 10000 structural models built by Modeller [44] with a structural electrostatic perspective