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Semaglutide withdrawal also commonly involves a return of heightened appetite and food cravings

This triple-agonist design incorporates GIP receptor activation alongside the GLP-1 and glucagon pathways

Gastrointestinal side effects Nausea is dose-dependent, ranging from approximately 14% at 1 mg to 60% at 12 mg, mostly during titration

Even within the food domain, several methodological issues make summarizing data across studies difficult: studies enrolled small sample sizes, used diverse pharmacological agents (e.g., exenatide, liraglutide, lixisenatide) with different dosing regimens, and mixed acute versus chronic designs