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Elegant studies from Blumberg and colleagues have also revealed that in specifically hematopoietic cells, FcRn has a role in antigen presentation [86,87,88] and binding of immune complexes (ICs) taken up by the activating Fc gamma (Fc) receptor IIa [89], which links it to the inflammatory potential of ICs and T cell activation [90,91,92]
it also increases total exposure and cost
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its overexpression induces the production and release of inflammatory factors, which are important drivers of carcinogenesis and cancer progression
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