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2011 Demonstrated neuroprotective effects in traumatic brain injury and peripheral nerve damage models with improved recovery markers

NMN targets NAD+ decline and Sirtuin-driven DNA repair

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The mechanism of this combined effect appears to be sequential: TB-500 mobilizes and migrates repair cells to the injury site (via actin regulation and chemotactic signaling), while BPC-157 creates the optimal local microenvironment (via angiogenesis, growth factor expression, and NO modulation) for those cells to perform effective repair once they arrive