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Patients with the temporal lobe epilepsy-depression (TLE-D) phenotype are more prone to cognitive impairment, a finding that further supports the notion that TLE may affect both cognitive and emotional functions through multiple pathophysiological mechanisms (Bingaman et al., 2023)

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391,392 The contradictory role of SIRT1 in cancer is manifested as their overexpression in neoplasms, such as prostate, AML, non-melanoma or melanoma skin cancer, and colon carcinomas, and the reduced expression in other cancers, including breast cancer and hepatic cell carcinomas